Diaspora Peserta SCKD 2019

Dr. Teguh Haryo Sasongko MD, PhD

NegaraMalaysia

Foto Diri
Biografi Singkat

Dr Teguh Haryo Sasongko is currently the Deputy Director of Perdana University Center for Research Excellence. He is also an Associate Professor at the Perdana University RCSI (Royal College of Surgeons in Ireland) School of Medicine. He completed his training as a medical doctor at the School of Medicine, Universitas Gadjah Mada, Indonesia in 2003. He obtained his doctoral degree on Human Molecular Genetics from the Graduate School of Medicine, Kobe University, Japan in 2008 through a Japanese Government’s Monbukagakusho Scholarship. He is an active author and trainer for The Cochrane Collaboration, a prominent worldwide evidence-based healthcare initiative. He is currently leading a national project in Cochrane Malaysia that aims at delivering the content of Cochrane evidence to the public. He was a Japanese Society for the Promotion of Science (JSPS) Research Fellow in the Department of Biomedical Ethics and Public Policy, Osaka University. Dr. Teguh has been actively publishing in national and international peer-reviewed journals and book chapters in the fields of human molecular genetics, bioethics, and systematic reviews, besides serving as reviewers for numerous international journals. He was one of the finalists of Mark S Ehrenreich Award during the 10th World Congress of Bioethics in 2010. His research has been focusing on the molecular genetics and therapeutic studies of single-gene disorders and complex multifactorial disorders that include Diabetes, Cerebral Palsy, Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, and Tuberous Sclerosis Complex. His research also involves ethical and social issues on human/medical genetics, especially that related to Malaysian society. He has been instrumental in formulating the current ethical guidelines and template of informed consent form for human genetic and genomic research in Universiti Sains Malaysia.

link laman Profesional

https://scholar.google.com/citations?user=sfAuoBgAAAAJ&hl=en, http://www.researcherid.com/rid/B-5515-2011, http://orcid.org/0000-0002-6226-6264, https://www.scopus.com/authid/detail.uri?authorId=12786227400, https://www.researchgate.net/profile/Teguh_Haryo_Sasongko

Riwayat Pendidikan
Jenjang Institusi Fakultas/Bidang Tahun (mulai – selesai)
Medical Doctor Universitas Gadjah Mada Fakultas Kedokteran 1996 – 2003
Doctor of Philosophy Kobe University Graduate School of Medicine 2003 – 2008
Riwayat Pekerjaan Formal
Institusi Posisi/Jabatan Tahun
Universiti Sains Malaysia, School of Medical Sciences Postdoctoral Fellow 2008
Universiti Sains Malaysia, School of Medical Sciences Senior Lecturer 2009 – 2016
International Medical University Associate Professor 2017 – 2018
Institusi Saat ini

Perdana University RCSI (Royal College of Surgeons in Ireland) School of Medicine and Perdana University Center for Research Excellence

Posisi/Jabatan di Institusi (Lainnya)

Deputy Director Perdana University Center for Research Excellence, Associate Professor Perdana University RCSI School of Medicine

Bidang Ilmu

Molecular Genetics, Medical/Research Ethics, Systematic Review

Fokus Penelitian
  • Molecular genetics and therapeutic studies of single-gene disorders and complex multifactorial disorders, including Diabetes, Cerebral Palsy, Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, Tuberous Sclerosis Complex, ethical and social issues of human/medical genetics, and systematic reviews of intervention studies as well as genetic association studies
Publikasi
Judul Nama Jurnal Tahun
Antiphospholipid antibodies in epilepsy: A systematic review and meta-analysis. 2018
Placebo Controlled Trials: Interests of Subjects versus Interests of Drug Regulators. 2017
A 15-year single centre retrospective study of antiphospholipid syndrome patients from Northern Malaysia. 2017
Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis. 2017
Social and Communicative Functions of Informed Consent Forms in East Asia and Beyond. 2017
Combination of Multiple Ligation-Dependent Probe Amplification and Illumina MiSeq Amplicon Sequencing for TSC1/TSC2 Gene Analyses in Patients with Tuberous Sclerosis Complex. 2017
Therapeutic Suppression of Nonsense Mutation: An Emerging Target in Multiple Diseases and Thrombotic Disorders. 2017
Familial primary antiphospholipid syndrome: A report of co-occurrence in three Malaysian family members. 2016
‘Non-Criteria’ Neurologic Manifestations of Antiphospholipid Syndrome: A Hidden Kingdom to be Discovered. 2016
Rapamycin and rapalogs for tuberous sclerosis complex. 2016
Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients. 2016
Antiphospholipid Antibody-Mediated Thrombotic Mechanisms in Antiphospholipid Syndrome: Towards Pathophysiology-Based Treatment. 2016
Type 2 Diabetes Mellitus and Alzheimer’s Disease: Bridging the Pathophysiology and Management. 2016
DNA Methylation: An Epigenetic Insight into Type 2 Diabetes Mellitus. 2016
Natural Products Towards the Discovery of Potential Future Antithrombotic Drugs. 2016
Informed Consent Template and Guidelines on the Ethical Practice in Human Genetics and Human Genomic Research; Initiatives of the Universiti Sains Malaysia. 2015
Nomenclature Confusion in Deletion Mutations Involving Repetitive Nucleotides: A Lesson from HBB Gene Codon 35 (-C) vs. Codon 36 (-C). 2015
Rapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta-analysis. 2015
Angiotensin-converting enzyme (ACE) inhibitors for proteinuria and microalbuminuria in people with sickle cell disease. 2015
Macrodactyly and poliosis in tuberous sclerosis complex. 2014
Two novel gross deletions of TSC2 in Malaysian patients with tuberous sclerosis complex and TSC2/PKD1 contiguous deletion syndrome. 2014
Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy 2013
Novel complex re-arrangement of ARG1 commonly shared by unrelated patients with hyperargininemia. 2014
Mutation spectrum of dystrophin gene in malaysian patients with Duchenne/Becker muscular dystrophy. 2013
Allele-specific PCR for a cost-effective & time-efficient diagnostic screening of spinal muscular atrophy. 2012
Two closely spaced nonsense mutations in the DMD gene in a Malaysian family. 2011
Analysis of sequence variations in low-density lipoprotein receptor gene among Malaysian patients with familial hypercholesterolemia. 2011
Deletion analysis of SMN1 exon 7 alone may be necessary and sufficient for the diagnosis of spinal muscular atrophy. 2011
Permissibility of prenatal diagnosis and abortion for fetuses with severe genetic disorder: type 1 spinal muscular atrophy. 2010
MERCI: a useful systematic ‘aide memoir’ to help clinicians teach ethics. 2009
Screening of the LIX1 gene in Japanese and Malaysian patients with SMA and/or SMA-like disorder. 2010
Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy. 2009
Novel mutations in 21 patients with tuberous sclerosis complex and variation of tandem splice-acceptor sites in TSC1 exon 14. 2008
SMN2 and NAIP gene dosages in Vietnamese patients with spinal muscular atrophy. 2008
Germ-line mutation of KCNQ2, p.R213W, in a Japanese family with benign familial neonatal convulsion. 2008
Hypomutability at the polyadenine tract in SMN intron 3 shows the invariability of the a-SMN protein structure. 2008
Nonsense mutations of the ZFHX1B gene in two Japanese girls with Mowat-Wilson syndrome. 2007
A novel mutation at the N-terminal of SMN Tudor domain inhibits its interaction with target proteins. 2007
C117T variant in the SMN1 gene found in the Japanese population. 2007
ACE gene polymorphism in children with nephrotic syndrome in the Indonesian population. 2005
Keanggotaan dan Penghargaan
Nama Tahun Organisasi Pemberi
2016
2016 – present
2014 – present
2017 – present
2017 – present
2013 – 2014
2012
2015
2015
2014
2014
2014
2013
2012
2012
2012
2010
2010, 2012
Daftar Hibah yang Diperoleh
Judul, role Tahun Jumlah Dana Pemberi Hibah
Title: Genetic Host Susceptibility Factors to Severe Dengue Infection – A Systematic Review, Role: Principal Investigator 2018 MYR 20,000 International Medical University
Title : Cell-Based Bioassays And Virtual Molecular Docking For Elucidating The Effects Of Malaysian-Derived mTOR Inhibitor Substances On A Tuberous On A Tuberous-Sclerosis-Complex-Derived Tumor Cells, Role : Principal Investigator, turned into Co-Investigator (change of employment) 2014 – 2018 MYR 231,776.00 Universiti Sains Malaysia
Community Outreach for the Promotion of Public Awareness on Genetic Disorders; Targeting General Public and Patients/Families; Role: Project Head 2014 – 2016 MYR 159,999.90 Ministry of Education, Malaysia
4. Title: Influence of ACE I/D Polymorphism on the Performance of Malay Male School Children in Endurance Type Sport; Role : Principal Investigator 2012 – 2015 MYR 37,310.00 Universiti Sains Malaysia
5. Title: Qualitative and Quantitative Analyses Of SMN 2 Gene Expression Upon Expression with Histone De-acetylase Inhibitors and Polyphenols; Role: Principal Investigator 2010 – 2014 MYR 220,157 Universiti Sains Malaysia
6. Title: Development Of Mutation Screening For The Molecular Diagnosis Of Tuberous Sclerosis Complex; Role : Principal Investigator 2009 – 2011 MYR 150,547.00 Universiti Sains Malaysia
Title: Significance of Exonic Splicing Enhancer (ESE) Motifs in The Splicing Mechanism within Internal Exons of SMN Genes; Role: Co-Investigator 2009 – 2011 MYR 38,881.00 Universiti Sains Malaysia
Title: Codon-Correction-Inframing Approach For The Repair Of Dystrophin Gene Mutation In Duchenne Muscular Dystrophy Patients; Role: Co-Investigator 2010 – 2014 MYR 204,741.00 Universiti Sains Malaysia
Title: Analysis of Genetic Polymorphism as Risk Factors for Type 2 Diabetes Mellitus Among Malaysian Malay : A Pharmacogenetic Study; Role: Co-Investigator 2011 – 2015 MYR 211,528.00 Universiti Sains Malaysia
10. Title: A Study on Isodiospyrin Putative Inhibitory actions against exonic splicing enhancers of dystrophin gene exon skipping in Duchenne Muscular Dystrophy; Role: Co-Investigator 2012 – 2016 MYR 223,150.00 Universiti Sains Malaysia
11. Title: A Study on the Association Among ACTN3 R577X Polymorphism, Sprint Achievement and Academic Performance in Malay Male School Children; Role: Co-Investigator 2012 – 2015 MYR 40,000.00 Universiti Sains Malaysia
Title : Neurology & Psychiatry – Pediatric Neurology; Role: Co-Investigator 2012 – 2015 MYR 700,000 Ministry of Education, Malaysia
Title: Novel Approaches To Detection Of Disease Recurrence, Risk Reduction And Improved Management Of Breast Cancer; Role: Co-Investigator 2013 – 2016 MYR 906,644 Universiti Sains Malaysia
Title: Genome Wide Gene Promoter DNA Methylation Study On Response To Oral Anti-Diabetics In Malay Male Patients With Type 2 Diabetes Mellitus (T2DM); Role: Co-Investigator 2014 – 2017 MYR 196,308.00 Universiti Sains Malaysia
Anggota Asosiasi Profesional
Judul Tahun
Forum for the Ethical Review Committees of the Asia and Western Pacific 2013 – present
Genetics Society of Malaysia 2009 – present
Medical Genetics Society of Malaysia 2011 – present
Malaysian Society for Biochemistry and Molecular Biology 2011 – present