Diaspora Peserta SCKD 2019

Dr. Delvac Oceandy MD, PhD

NegaraUnited Kingdom

Foto Diri
Biografi Singkat

Delvac Oceandy is a Reader in Cardiovascular Biology at The University of Manchester, UK. He graduated as an MD at Universitas Airlangga, Indonesia and received his PhD in Molecular Genetics from University of Queensland, Australia. After completing his PhD he joined the laboratory of Professor Ludwig Neyses in Manchester as a postdoctoral scientist. Delvac won the prestigious European Society of Cardiology Young Investigator Award in Basic Science in 2006. He was then awarded the British Heart Foundation (BHF) Intermediate Fellowship in 2010, which enabled him to develop his own laboratory at Division of Cardiovascular Sciences, University of Manchester. His lab is focusing on studying the molecular aspects of heart failure and left ventricular remodelling, in particular in understanding the mechanisms underlying myocardial hypertrophy and regeneration of heart muscle. Recently, he is also involved in several clinical and population studies on cardiovascular diseases. His work is supported by multiple grants from the British Heart Foundation (BHF) and Medical Research Council (MRC) and his research standing is recognised by appointments to serve on the BHF Grant Panel Committee and editorial board membership of top journals including Scientific Reports. He also hold several external appointments as Adjunct Professor in Biomedical Science at Universitas Airlangga and Visiting Lecturerships at Universitas Brawijaya and Universitas Gajah Mada.

link laman Profesional

https://www.research.manchester.ac.uk/portal/delvac.oceandy.html

Riwayat Pendidikan
Jenjang Institusi Fakultas/Bidang Tahun (mulai – selesai)
S1 Universitas Airlangga Kedokteran 1989-1996
S2 University of Queensland Molecular Biology 1996-1998
S3 University of Queensland Molecular Genetics 1998-2002
Riwayat Pekerjaan Formal
Institusi Posisi/Jabatan Tahun
Lembaga Biologi Molekuler Eijkman Research Assistant 1996-1998
Institute of Molecular Biosciences, University of Queensland Research Assistant 2001-2002
University of Manchester Research Associate 2002-2007
University of Manchester Research Fellow 2007-2010
University of Manchester Lecturer 2010-2014
University of Manchester Senior Lecturer 2014-2019
University of Manchester Reader 2019 – present
Institusi Saat ini

Division of Cardiovascular Sciences, School of Medicine, University of Manchester

Posisi/Jabatan di Institusi (Lainnya)

Reader

Bidang Ilmu

Molecular biology, Cardiovascular medicine

Fokus Penelitian
  • Cardiac regeneration
  • Stem cell treatment
  • Heart Failure
Publikasi
Judul Nama Jurnal Tahun
Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response. Circulation Research 2019
Cardiovascular disease risk factor prevalence and estimated 10-year cardiovascular risk scores in Indonesia: The SMARThealth Extend study. PLoS One 2019
RNA extraction from self-assembling peptide hydrogels to allow qPCR analysis of encapsulated cells. PLoS One 2018
Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nature Communications 2017
Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia. Circulation Research 2017
An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility. Journal of Clinical Investigation 2017
Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion. Journal of Molecular and Cellular Cardiology 2017
The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease. Physiological Reviews 2017
Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival. Stem Cell Research 2017
One-Month Global Longitudinal Strain Identifies Patients Who Will Develop Pacing-Induced Left Ventricular Dysfunction over Time: The Pacing and Ventricular Dysfunction (PAVD) Study. PLoS One 2017
Western blot analysis of cells encapsulated in self-assembling peptide hydrogels. Biotechniques 2017
Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide. FEBS Open Bio 2017
The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochem Biophys Research Communications 2016
The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy. Nature Communications 2016
Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin. Arterioscler Thromb Vasc Biol 2014
The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy. Journal of Biological Chemistry 2014
The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes. Cardiovascular Research 2014
Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump–a novel therapeutic target for contraception and malaria. J Pharm Pharm Sci 2013
Development and characterization of a novel fluorescent indicator protein PMCA4-GCaMP2 in cardiomyocytes. Journal of Molecular and Cellular Cardiology 2013
Pacing-induced cardiomyopathy: pathophysiological insights through matrix metalloproteinases. Heart Failure Review 2014
A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin. Circulation Heart Failure 2013
Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells. Carcinogenesis 2012
Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain. J Biol Chem 2011
Ca2+ signalling in cardiovascular disease: the role of the plasma membrane calcium pumps. Sci China Life Sci 2011
Calcium signaling dysfunction in heart disease. Biofactors 2011
Local signals with global impacts and clinical implications: lessons from the plasma membrane calcium pump (PMCA4). Biochim Biophys Acta 2011
Ras-association domain family member 1A (RASSF1A)-where the heart and cancer meet. Trends cardiovasc Med 2009
Measurement of plasma membrane calcium-calmodulin-dependent ATPase (PMCA) activity. Methods Mol Biol 2010
Endothelial nitric oxide synthase activity is inhibited by the plasma membrane calcium ATPase in human endothelial cells. Cardiovascular Research 2010
Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circulation Research 2010
Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy. Circulation 2009
Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. J Biol Chem 2009
Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth. Circulation Research 2009
Physiological implications of the interaction between the plasma membrane calcium pump and nNOS. Pflugers Arch 2009
Targeting the sarcolemmal calcium pump: a potential novel strategy for the treatment of cardiovascular disease. Cardiovasc Hematol Agents Med Chem. 2007
The regulatory function of plasma-membrane Ca(2+)-ATPase (PMCA) in the heart. Biochem Soc Trans. 2007
Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients. Eur J Heart Fail 2007
Plasma membrane calcium ATPase and its relationship to nitric oxide signaling in the heart. Ann N Y Acad Sci. 2007
Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b. Circulation 2007
The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex. J Biol Chem 2006
The emergence of plasma membrane calcium pump as a novel therapeutic target for heart disease. Mini Rev Med Chem 2006
The sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit. J Biol Chem 2005
Novel functional interaction between the plasma membrane Ca2+ pump 4b and the proapoptotic tumor suppressor Ras-associated factor 1 (RASSF1). J Biol Chem 2004
Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. J Biol Chem 2004
GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon. J Membr Biol 2003
A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 2003
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Human Molecular Genetics 2002
A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J Leukoc Biol 2001
G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease. Am J Physiol Lung Cell Mol Physiol 2001
Keanggotaan dan Penghargaan
Nama Tahun Organisasi Pemberi
British Heart Foundation Project Grant Committe Member 2015-now British Heart Foundation
Editorial Board Nature Scientific Reports 2016-now Nature Scientific Reports
British Heart Foundation Intermediate Fellow 2010-2015 British Heart Foundation
ESC Young Investigator Award (1st winner) 2006 European Society of Cardiology
ESC Best Presented paper 2012 European Society of Cardiology
AMP Queensland Biomedical Research Award (1st Winner) 2001 Australian Society for Medical Research
Daftar Hibah yang Diperoleh
Judul, role Tahun Jumlah Dana Pemberi Hibah
Does PMCA4 inhibition protect the heart from acute cardiac death following myocardial infarction?, Principal Investigator (PI) 2018-2020 £162.253 British Heart Foundation
Targeting the Hippo pathway to enhance the regenerative capacity of iPS‐derived cardiomyocytes. (PI) 2018-2021 £224.780 British Heart Foundation
Control of ion channel expression in the cardiac conduction system in disease – search for potential new therapeutic targets. (co-investigator) 2018-2023 £1.326.626 British Heart Foundation
The role of plasma membrane calcium ATPase 4 (PMCA4) in modulating Plasmodium infection and malaria severity, principal investigator 2017-2019 £275.650 MRC-DIPI
Modulation of calcium signalling in cardiac fibroblasts by the Plasma Membrane Calcium Pumps (PMCA) to improve pathological cardiac remodelling., principal investigator 2016-2018 £137.281 British Heart Foundation
Developing genomic medicine between Africa and the UK, co-investigator 2015-2016 £165.030 ESRC-Newton Fund
Molecular mechanisms underlying exercise training-induced arrhythmia., co-investigator 2014-2017 £180.684 British Heart Foundation
Signal modulation in cardiac fibroblasts by the plasma membrane calcium ATPase 4 (PMCA4) controls cardiac hypertrophy, principal investigator 2013-2016 £202.000 British Heart Foundation
The Role of RASSF1A (Ras Association Domain Family Protein 1A) and Mst2 (Mammalian Sterile20-like 2) Signalling Network in Myocardial Hypertrophy, principal investigator 2010-2015 £546.475 British Heart Foundation
The protective role of Interleukin-10 receptor signalling in the heart, principal investigator 2011-2014 £62.200 British Heart Foundation
Targeting PMCA4 for malaria treatment, principal investigator 2013-2014 £10.000 British Council
Anggota Asosiasi Profesional
Judul Tahun
Member of European Society of Cardiology Working Group of Cellular Biology of the Heart ongoing
Member of Heart Failure Association of the ESC ongoing
Member of British Society of Cardiovascular Research ongoing