Diaspora Peserta SCKD 2018

Dr. Alfi Khatib

NegaraMalaysia

Foto Diri
Biografi Singkat

Dr. Alfi Khatib menyelesaikan program kesarjanaan di Institut Pertanian Bogor di bidang kimia pangan pada tahun 1994. Beliau melanjutkan studi S2 dan S3 di bidang Natural Products and Drug Discovery di Universitas Leiden (Belanda) dan mendapatkan gelar doktor pada tahun 2006. Selama 2 tahun beliau menjadi post doctoral researcher di universitas yang sama untuk mendalami kajian metabolomics. Pada tahun 2008, beliau bergabung dengan Univeristi Putra Malaysia (UPM) sebagai dosen senior sebelum pada akhirnya beliau bergabung dengan International Islamic University Malaysia (IIUM) sebagai Associate professor pada tahun 2013. Beliau telah menghasilkan lebih dari 100 publikasi ilmiah berimpak faktor tinggi (h-index scopus=17), paten internasional, dan buku ilmiah. Berbagai penghargaan tingkat nasioanal dan internasional telah beliau terima salah satunya adalah pemenang Dutch New Venture Competition 2006, dan outstanding researcher dari UPM dan IIUM dari tahun 2010-2018. Saat ini beliau fokus dalam penelitian “natural products and drug discoveries” menggunakan tanaman obat tradisional baik dari Malaysia maupun dari Indonesia.

link laman Profesional

https://scholar.google.com/citations?user=0OqlP-MAAAAJ&hl=en

Riwayat Pendidikan
Jenjang Institusi Fakultas/Bidang Tahun (mulai – selesai)
S1 Institui Pertanian Bogor Teknologi Pertanian/Kimia Pangan 1989-1994
S2 Leiden University Natural Products and Drug Discoveries 1999-2000
S3 Leiden University Natural Products and Drug Discoveries 2003-2006
Riwayat Pekerjaan Formal
Institusi Posisi/Jabatan Tahun
Leiden University Post Doctoral Fellow 2006-2008
Universiti Putra Malaysia Senior Lecturer 2008-2013
International Islamic University Malaysia Associate Professor 2013-sekarang
Institusi Saat ini

Faculty of Pharmacy, International Islamic University Malaysia

Bidang Ilmu

Pharmaceutical Chemistry

Fokus Penelitian
  • Natural Products and Drug Discoveries
  • Metabolomics
Publikasi / Paten
Judul Nama Jurnal Tahun
Review: The promise of zebrafish as a model of metabolic syndrome 2019
Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking 2019
Anticancer Activity of Grassy Hystrix brachyura Bezoar and Its Mechanisms of Action: An in vitro and in vivo based study 2019
Optimization of hyperglycemic induction in zebrafish and evaluation of its blood glucose level and metabolite fingerprint treated with Psychotria malayana Jack leaf extracts 2019
Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting 2019
Influence of origins and bee species on physicochemical, antioxidant properties and botanical discrimination of stingless bee honey 2019
Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts 2019
GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity 2019
Antioxidant Activities of Dialium indum L. Fruit and Gas Chromatography-Mass Spectrometry (GC-MS) of the Active Fractions 2018
Saffron (Crocus sativus L.): As an antidepressant 2018
Chemical Profile, Total Phenolic Content, DPPH Free Radical Scavenging and á-Glucosidase Inhibitory Activities of Cosmos Caudatus Kunth Leaves. 2018
Antiradical and Xanthine Oxidase Inhibitory Activity Evaluations of Averrhoa bilimbi L. Leaves and Tentative Identification of Bioactive Constituents through LC-QTOF-MS/MS and Molecular Docking Approach 2018
Phytoconstituents from Vernonia glaberrima Welw. Ex O. Hoffm. leaves and their cytotoxic activities on a panel of human cancer cell lines 2018
Metabolomic analysis and biochemical changes in the urine and serum of streptozotocin-induced normal-and obese-diabetic rats. 2018
Effects of different types of soy sauce on the formation of heterocyclic amines in roasted chicken. 2018
Comparative Analysis of Chemical Composition, Antioxidant Activity and Quantitative Characterization of Some Phenolic Compounds in Selected Herbs and Spices in Different Solvent Extraction Systems 2018
Comparison of partial least squares and random forests for evaluating relationship between phenolics and bioactivities of Neptunia oleracea. 2018
Inhibitory effect of mixture herbs/spices on formation of heterocyclic amines and mutagenic activity of grilled beef 2018
Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square. 2018
Classification of Raw Stingless Bee Honeys by Bee Species Origins Using the NMR-and LC-MS-Based Metabolomics Approach 2018
Characterization of α-Glucosidase Inhibitors from Clinacanthus nutans Lindau Leaves by Gas Chromatography-Mass Spectrometry-Based Metabolomics and Molecular Docking Simulation 2018
Effect of Ipomoea aquatic ethanolic extract in stremprozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach. 2017
Application of BATMAN and BAYESIL for quantitative 1H-NMR based metabolomics of urine: discriminant analysis of lean, obese, and obese-diabetic rats 2017
Discriminative Analysis of Different Grades of Gaharu (Aquilaria malaccensis Lamk.) via 1H-NMR-Based Metabolomics Using PLS-DA and Random Forests Classification Models. 2017
Characterization of antioxidant activity of Momordica charantia fruit by infrared based fingerprinting. 2017
Low inhibition on alpha glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit. 2017
Glucosidase Inhibitory and Antioxidant Activities of Different Ipomoea aquatica Cultivars and LC–MS/MS Profiling of the Active Cultivar. 2017
Rapid investigation of α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using FTIR-ATR based fingerprinting. 2017
Identification of bioactive compounds with GC–Q-TOF–MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction. 2017
In vitro antioxidant and, α-glucosidase inhibitory activities and comprehensive metabolite profiling of methanol extract and its fractions from Clinacanthus nutans. 2017
Urinary metabolic profiling of cisplatin nephrotoxicity andnephroprotective effects of Orthosiphon stamineus leaves elucidated by1H NMR spectrsocopy. 2017
Characterization of Metabolite Profile in Phyllanthus niruri and Correlation with Bioactivity Elucidated by Nuclear Magnetic Resonance Based Metabolomics. 2017
Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats via 1H NMR spectroscopy. 2017
Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet. 2017
Discrimination of Ipomoea aquatica cultivars and bioactivity correlations using NMR- based metabolomics approach 2017
Authentication of butter from lard adulteration using high-resolution of nuclear magnetic resonance spectroscopy and high-performance liquid chromatography. 2017
Antioxidant and α-glucosidase inhibitory activities of isolated compounds from Ipomoea aquatica. 2016
Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract. 2016
Clinacanthus nutans: A review of the medicinal uses, pharmacology and phytochemistry. 2016
An investigation into the anti-obesity effects of Morinda citrifolia L. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach. 2016
Effect of Different Drying Treatments and Solvent Ratios on Phytochemical Constituents of Ipomoea aquatica and Correlation with α-Glucosidase Inhibitory Activity. 2016
Metabolite profiling of Neptunia oleracea and correlation with antioxidant and α-glucosidase inhibitory activities using 1H NMR-based metabolomics. 2016
Comparative evaluation of nutritional compositions, antioxidant capacities, and phenolic compounds of red and green sessile joyweed (Alternanthera sessilis). 2016
Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract. 2016
Chemical profiling of different types of soy sauce and the relationship with its sensory attributes. 2016
Differentiation of fatty acid composition of butter adulterated with lard using gas chromatography mass spectrometry combined with principle compnent analysis. 2016
Screening of various parts of Phaleria macrocarpa plant for α-glucosidase inhibitory activity. 2015
Phytochemical diversity of Clinacanthus nutansextracts and their bioactivity correlations elucidated by NMR based metabolomics. 2015
Phytochemical and biological features of Phyllanthus niruri and Phyllanthus urinaria harvested at different growth stages revealed by 1H NMR-based metabolomics. 2015
Infrared–metabolomics approach in detecting changes in Andrographis paniculata metabolites due to different harvesting ages and times. 2015
Multivariate analysis of PRISMA optimized TLC image for predicting antioxidant activity and identification of contributing compounds from Pereskia bleo. 2015
Effect of storage time on metabolite profile and alpha-glucosidase inhibitory activity of Cosmos caudatus leaves – GCMS based metabolomics approach. 2015
Metabolite profiling of Ipomoea aquatica at different growth stages in correlation to the antioxidant and α-glucosidase inhibitory activities elucidated by 1H NMR-based metabolomics. 2015
Evaluation of antidiabetic properties of Momordica charantia in streptozotocin induced diabetic rats using metabolomics approach. 2015
Relationship Between Metabolites Composition and Biological Activities of Phyllanthus niruri Extracts Prepared by Different Drying Methods and Solvents Extraction. 2015
Detection of Butter Adulteration with Lard by Employing 1H-NMR Spectroscopy and Multivariate Data Analysis. 2015
Detection of butter adulteration with lard using differential scanning calorimetry 2015
FTIR-ATR Spectroscopy Based Metabolite Fingerprinting as A Direct Determination of Butter Adulterated With Lard. 2015
Orthogonal Partial Least Squares Model for Rapid Prediction of Antioxidant Activity of Pereskia bleo by Fourier Transform Infrared Spectroscopy. 2014
GC‐MS‐Based Metabolite Profiling of Cosmos caudatus Leaves Possessing Alpha‐Glucosidase Inhibitory Activity. 2014
Effects of Different Drying Methods and Storage Time on Free Radical Scavenging Activity and Total Phenolic Content of Cosmos Caudatus. 2014
Chemical characterization and antioxidant activity of three medicinal Apiaceae species. 2014
Effect of Cosmos caudatus Kunth leaves on the lipid profile of a hyperlipidemia-induced animal model. 2014
The Influence of Deep Frying Using Various Vegetable Oils on Acrylamide Formation in Sweet Potato (Ipomoea batatas L. Lam) Chips. 2014
Comparison of Partial Least Squares and Artificial Neural Network for the prediction of antioxidant activity in extract of Pegaga (Centella) varieties from 1H Nuclear Magnetic Resonance spectroscopy. 2013
Headspace solid-phase microextraction gas chromatography–mass spectrometry determination of volatile compounds in different varieties of African star apple fruit (Chrysophillum albidum). 2013
Cosmos caudatus as a Potential Source of Bioactive Compounds: Optimisation of Oven Drying Conditions and Characterisation of its Functional Properties. 2013
Simultaneous determination of aflatoxins, ochratoxin A, and zearalenone in cereals using a validated RP-HPLC method and phred derivatization system. 2013
Quantification of Escherichia coli O157:H7 in organic vegetables and chickens. 2013
Risk of Escherichia coli O157:H7 transmission linked to the consumption of raw milk. 2013
Application of FTIR-ATR Spectroscopy Coupled with Multivariate Analysis for Rapid Estimation of Butter Adulteration. 2013
Biochemical properties of red tilapia (Oreochromis niloticus) protein hydrolisates. 2013
1H-NMR-based metabolomics approach to understanding the drying effects on the phytochemicals in Cosmos caudatus. 2012
High-performance liquid chromatographic determination of 5-hydroxymethyl furfural in roasted plantain cultivars. 2012
Influence of Growth Stage and Season on the Antioxidant Constituents of Cosmos caudatus. 2012
Plants’ Metabolites as potential Anti Obesity Agents. 2012
Antioxidant activity of different extracts from leaves of Pereskia bleo (Cactaceae). 2012
Volatile compounds of roasted and steamed Malaysian tropical almond nuts (T. catappa L). 2012
Oxidative behaviour of four Malaysian edible plant extracts in model and food oil systems. 2012
Discrimination of three Pegaga (Centella) varieties and determination of growth-lighting effects on metabolites content based on chemometry of 1H Nuclear Magnetic Resonance spectroscopy. 2012
Role of health hazardeous ethephone on nutritive values of selected pineapple, banana and tomato. 2012
A UPLC-MS/MS for simultaneous determination of aflatoxins, ochratoxin A, zearalenone, DON, fumonisins, T-2 toxin and HT-2 toxin, in cereals. 2012
Metabolic characterization of green pods from Vanilla planifolia accessions grown in La Réunion. 2011
Comprehensive Extraction Method Integrated with NMR Metabolomics: A New Bioactivity Screening Method for Plants, Adenosine A1 Receptor Binding Compounds in Orthosiphon stamineus Benth. 2011
Antimicrobial activities of selected Malaysian plants against several food borne pathogen bacteria. 2011
Discrimination of Young and Mature Leaves of Melicope ptelefolia using 1H NMR and Multivariate Data Analysis. 2011
Metabolomics for bioactivity assessment of natural products. 2011
Sample preparation optimization for the simultaneous determination of mycotoxins in cereals. 2011
Simultaneous detection of 12 mycotoxins in cereals using RP-HPLC-PDA-FLD with PHRED and post-column derivatization system. 2011
Extraction of fish oil from the skin of Indian mackerel using supercritical fluids. 2010
Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L. 2010
Fatty Acid Compositions of Fish Oil Extracted from Different Parts of Indian Mackerel (Rastrellinger kanagurta) using Various Techniques of Supercritical CO2 Extraction. 2010
Application of Two Dimensional Thin Layer Chromatography Pattern Comparison for Fingerprinting the Active Compounds in the Leaves of Vitex trifolia Linn Possessing Anti-Tracheospasmolytic Activity. 2010
The Application of β-Cyclodextrin to Separate cis- from trans- Iso-alpha-Acids in an Isomerized Hop Extract. 2010
Isolation of individual hop iso-alfa-acids stereoisomers by beta-cyclodextrin. 2010
Storage stability of fish oil from Langkawi island, Malaysia. 2009
Metabolic changes in different developmental stages of Vanilla planifolia pods. 2009
Identification of Possible Compounds Possessing Adenosine A1 Receptor Binding Activity in the leaves of Orthosiphon stamineus Using TLC and Multivariate Data Analysis. 2009
Adenosine A1 Receptor Binding Activity of Methoxy Flavonoids from Orthosiphon stamineus. 2009
NMR assignment of iso-alpha-acids from isomerized extract of Humulus lupulus L., cones. 2007
High performance liquid chromatography method of iso-alpha-acids. 2006
Anti-inflammatory activities of Cinnamomum burmanni Bl. 2005
Studies of iso-alpha-acids. 2006
Method of improving the stability of hop extracts and hop flavored beverages. 2006
Allergenicity study of white shrimp proteins (Paneus marguensis) for allergen isolate production. 1998
Characterization of tuna gastric protease as a rennet substitute. 1996
Keanggotaan dan Penghargaan
Nama Tahun Organisasi Pemberi
The winner of the Dutch New Venture Competition Round 2 2006 Duth Government
Excellent Achievement, 2009-2011 Universiti Putra Malaysia
Gold Medal for the invention of “FTIR-ATR Spectroscopy based metabolite fingerprinting as a direct determination of butter adulerated with lard” 2012 Universiti Putra Malaysia
Gold Medal for the invention of “Analysis of Butter Adulterated with Lard by FTIR and 1H-NMR for Halal Verification” 2012 Universiti Teknologi Mara Melaka
Department Best Non-Indexed Journal Articles 2015 International Islamic University Malaysia
Outstanding Contributor for Journal Articles Indexed in SCOPUS and WOS 2016 2016 International Islamic University Malaysia
The Most Productive Researcher Award 2017 International Islamic University Malaysia
Highest Number of Publication in Citation-Indexed Journals Award (Health and Medical). 2017 International Islamic University Malaysia
Best Journal Article Awards (Medical and Health Science) 2018 International Islamic University Malaysia
Highest Number of Publications Award: Indexed Journal Articles (Medical and Health Sciences) 2018 International Islamic University Malaysia
Outstanding contribution in Reviewing 2018 Phytomedicine-Elsevier
Daftar Hibah yang Diperoleh
Judul, role Tahun Jumlah Dana Pemberi Hibah
Understanding Anti-Angiogenesis Mechanism of Porcupine Bezoar Bioactive Compounds on Colon and Pancreas Cancer Cells Using Xenograft Zebrafish Model, anngota 2016-sekarang RM 100,000 Fundamental Research Grant Scheme (FRGS) from Malaysian Ministry of Higher Education
Understanding of anti-cancer properties of Neolamarckia cadamba leaves on breast cancer: Prospective therapeutic Neolamarckia cadamba extracts, Principal Investigator 2016-sekarang RM 52,200 Fundamental Research Grant Scheme (FRGS) from Malaysian Ministry of Higher Education
Multivariate calibration of anti-oxidant activity of Momordica charnatia fruit and its Fourier Transform Infra Red spectroscopy-based fingerprinting, Principal Investigator 2016-2017 RM 20,000 Research Initiative Grant Scheme from Malaysian Ministry of Higher Education
Evaluation of External Application of Halal Topical Cream of Neolamarckia Cadamba Leaves on Breast Cancer Cells in Rats Leading Towards Clinical Trial on Human Breast Cancer, member 2015-2016 RM 25,000 Research Initiative Grant Scheme from Malaysian Ministry of Higher Education
Effect of Standardized Extract of Clinacanthus Nutans in Hiperuricemia Induced Mice, member 2014-2017 RM 400,000 NKEA Research Grant Scheme (NRGS), Malaysia Ministry of Agriculture
Production of Chemical Markers From Labisia Pumila (Labisiaquinones B and Two Alkylresorcinols and Clinacanthus Nutans) Clinacosides A,B,C and Cycloclinacoside A2, Principal Investigator 2013-2015 RM 50,000 NKEA Research Grant Scheme (NRGS), Malaysia Ministry of Agriculture
Chemical Profiling of Mommordica Charantia Possessing Alpha-Glucosidase Inhibitory Activity using GC-MS based Metabolomics, member 2014-2016 RM 50,000 Research Acculturation Collaborative Effort (RACE) grant from Malaysian Ministry of Higher Education
Upscaling the Production of Novel Fucoxanthin from Malaysian Brown Algae for Food and Pharmaceutical Applications, member 2015-2016 RM 130,000 Prototype Research Grant Scehme (PRGS) from Malaysian Ministry of Higher Education
Fingerprinting of Sygygium Companulatum (Kelat Paya) Leaf Extracts Utilizing Gas Chromatography-Mass Spectrometery (GC-MS) and Metabolomics for their Quality and Efficacy Profile, member 2014-2016 RM 20,000 Endowment type B, International Islamic University Malaysia
Comprehensive evaluation of anti-diabetic activity of Momordica charantia fruits on streptozotocin induced diabetic rats using NMR metabolomics approach, Principal Investigator 2013-2015 RM 20,000 Endowment type B, International Islamic University Malaysia
Development of Validated Regression Model to Correlate Chemical Profile of the Leaves of Orthosiphon stamineus extract to Anti-Diabetic Activity using NMR and FTIR-based Metabolomics Approach, member 2011-2013 RM 400,000 NKEA Research Grant Scheme (NRGS), Malaysia Ministry of Agriculture
NMR based-metabolomics assessment of anti-diabetic effect of Cymbopogon citratus leaves on streptozotocin-induced diabetic rat, principal investigator 2012-2013 RM 100,000 Research University Grant Scheme (RUGS) Initiative 2 from UPM
Metabolomics study for the development of functional foods with anti-diabetic property, principal investigator 2011-2012 RM 370,000 Agro-Biothechnology R&D Initiatives, MOSTI
NMR based metabolomic biofluids of standardized Centella asiatica extract in the detection of physiological changes in rats induced diabetes, member 2010-2012 RM 60,000 Fundamental Research Grant Scheme (FRGS) from Malaysian Ministry of Higher Education
Study on antibacterial activity of Malaysian herbs and spices against food borne pathogen and food spoilage, principal investigator 2009-2011 RM 30,000 Research University Grant Scheme (RUGS) Initiative 4 from UPM
Feasibility study of the production of pure individual iso-alpha-acids, principal investigator 2006-2007 Euro 25,000 Dutch Valorization Grant
Anggota Asosiasi Profesional
Judul Tahun
American Chemical Society 2009-sekarang
Malaysian Natural Product Society 2015-sekarang
Malaysian Institute of Technology 2013-sekarang