Diaspora Peserta SCKD 2018
Dr. Alfi Khatib
NegaraMalaysia
Biografi Singkat
Dr. Alfi Khatib menyelesaikan program kesarjanaan di Institut Pertanian Bogor di bidang kimia pangan pada tahun 1994. Beliau melanjutkan studi S2 dan S3 di bidang Natural Products and Drug Discovery di Universitas Leiden (Belanda) dan mendapatkan gelar doktor pada tahun 2006. Selama 2 tahun beliau menjadi post doctoral researcher di universitas yang sama untuk mendalami kajian metabolomics. Pada tahun 2008, beliau bergabung dengan Univeristi Putra Malaysia (UPM) sebagai dosen senior sebelum pada akhirnya beliau bergabung dengan International Islamic University Malaysia (IIUM) sebagai Associate professor pada tahun 2013. Beliau telah menghasilkan lebih dari 100 publikasi ilmiah berimpak faktor tinggi (h-index scopus=17), paten internasional, dan buku ilmiah. Berbagai penghargaan tingkat nasioanal dan internasional telah beliau terima salah satunya adalah pemenang Dutch New Venture Competition 2006, dan outstanding researcher dari UPM dan IIUM dari tahun 2010-2018. Saat ini beliau fokus dalam penelitian “natural products and drug discoveries” menggunakan tanaman obat tradisional baik dari Malaysia maupun dari Indonesia.
link laman Profesional
https://scholar.google.com/citations?user=0OqlP-MAAAAJ&hl=en
Riwayat Pendidikan
| Jenjang | Institusi | Fakultas/Bidang | Tahun (mulai – selesai) |
|---|---|---|---|
| S1 | Institui Pertanian Bogor | Teknologi Pertanian/Kimia Pangan | 1989-1994 |
| S2 | Leiden University | Natural Products and Drug Discoveries | 1999-2000 |
| S3 | Leiden University | Natural Products and Drug Discoveries | 2003-2006 |
Riwayat Pekerjaan Formal
| Institusi | Posisi/Jabatan | Tahun |
|---|---|---|
| Leiden University | Post Doctoral Fellow | 2006-2008 |
| Universiti Putra Malaysia | Senior Lecturer | 2008-2013 |
| International Islamic University Malaysia | Associate Professor | 2013-sekarang |
Institusi Saat ini
Faculty of Pharmacy, International Islamic University Malaysia
Bidang Ilmu
Pharmaceutical Chemistry
Fokus Penelitian
- Natural Products and Drug Discoveries
- Metabolomics
Publikasi / Paten
| Judul | Nama Jurnal | Tahun |
|---|---|---|
| Review: The promise of zebrafish as a model of metabolic syndrome | 2019 | |
| Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking | 2019 | |
| Anticancer Activity of Grassy Hystrix brachyura Bezoar and Its Mechanisms of Action: An in vitro and in vivo based study | 2019 | |
| Optimization of hyperglycemic induction in zebrafish and evaluation of its blood glucose level and metabolite fingerprint treated with Psychotria malayana Jack leaf extracts | 2019 | |
| Rapid investigation of α-glucosidase inhibitory activity of Clinacanthus nutans leaf using infrared fingerprinting | 2019 | |
| Influence of origins and bee species on physicochemical, antioxidant properties and botanical discrimination of stingless bee honey | 2019 | |
| Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts | 2019 | |
| GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity | 2019 | |
| Antioxidant Activities of Dialium indum L. Fruit and Gas Chromatography-Mass Spectrometry (GC-MS) of the Active Fractions | 2018 | |
| Saffron (Crocus sativus L.): As an antidepressant | 2018 | |
| Chemical Profile, Total Phenolic Content, DPPH Free Radical Scavenging and á-Glucosidase Inhibitory Activities of Cosmos Caudatus Kunth Leaves. | 2018 | |
| Antiradical and Xanthine Oxidase Inhibitory Activity Evaluations of Averrhoa bilimbi L. Leaves and Tentative Identification of Bioactive Constituents through LC-QTOF-MS/MS and Molecular Docking Approach | 2018 | |
| Phytoconstituents from Vernonia glaberrima Welw. Ex O. Hoffm. leaves and their cytotoxic activities on a panel of human cancer cell lines | 2018 | |
| Metabolomic analysis and biochemical changes in the urine and serum of streptozotocin-induced normal-and obese-diabetic rats. | 2018 | |
| Effects of different types of soy sauce on the formation of heterocyclic amines in roasted chicken. | 2018 | |
| Comparative Analysis of Chemical Composition, Antioxidant Activity and Quantitative Characterization of Some Phenolic Compounds in Selected Herbs and Spices in Different Solvent Extraction Systems | 2018 | |
| Comparison of partial least squares and random forests for evaluating relationship between phenolics and bioactivities of Neptunia oleracea. | 2018 | |
| Inhibitory effect of mixture herbs/spices on formation of heterocyclic amines and mutagenic activity of grilled beef | 2018 | |
| Correlation of FT-IR Fingerprint and α-Glucosidase Inhibitory Activity of Salak (Salacca zalacca) Fruit Extracts Utilizing Orthogonal Partial Least Square. | 2018 | |
| Classification of Raw Stingless Bee Honeys by Bee Species Origins Using the NMR-and LC-MS-Based Metabolomics Approach | 2018 | |
| Characterization of α-Glucosidase Inhibitors from Clinacanthus nutans Lindau Leaves by Gas Chromatography-Mass Spectrometry-Based Metabolomics and Molecular Docking Simulation | 2018 | |
| Effect of Ipomoea aquatic ethanolic extract in stremprozotocin (STZ) induced diabetic rats via 1H NMR-based metabolomics approach. | 2017 | |
| Application of BATMAN and BAYESIL for quantitative 1H-NMR based metabolomics of urine: discriminant analysis of lean, obese, and obese-diabetic rats | 2017 | |
| Discriminative Analysis of Different Grades of Gaharu (Aquilaria malaccensis Lamk.) via 1H-NMR-Based Metabolomics Using PLS-DA and Random Forests Classification Models. | 2017 | |
| Characterization of antioxidant activity of Momordica charantia fruit by infrared based fingerprinting. | 2017 | |
| Low inhibition on alpha glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit. | 2017 | |
| Glucosidase Inhibitory and Antioxidant Activities of Different Ipomoea aquatica Cultivars and LC–MS/MS Profiling of the Active Cultivar. | 2017 | |
| Rapid investigation of α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using FTIR-ATR based fingerprinting. | 2017 | |
| Identification of bioactive compounds with GC–Q-TOF–MS in the extracts from Clinacanthus nutans using subcritical carbon dioxide extraction. | 2017 | |
| In vitro antioxidant and, α-glucosidase inhibitory activities and comprehensive metabolite profiling of methanol extract and its fractions from Clinacanthus nutans. | 2017 | |
| Urinary metabolic profiling of cisplatin nephrotoxicity andnephroprotective effects of Orthosiphon stamineus leaves elucidated by1H NMR spectrsocopy. | 2017 | |
| Characterization of Metabolite Profile in Phyllanthus niruri and Correlation with Bioactivity Elucidated by Nuclear Magnetic Resonance Based Metabolomics. | 2017 | |
| Urinary metabolomics study on the protective role of Orthosiphon stamineus in Streptozotocin induced diabetes mellitus in rats via 1H NMR spectroscopy. | 2017 | |
| Morinda citrifolia L. leaf extract prevent weight gain in Sprague-Dawley rats fed a high fat diet. | 2017 | |
| Discrimination of Ipomoea aquatica cultivars and bioactivity correlations using NMR- based metabolomics approach | 2017 | |
| Authentication of butter from lard adulteration using high-resolution of nuclear magnetic resonance spectroscopy and high-performance liquid chromatography. | 2017 | |
| Antioxidant and α-glucosidase inhibitory activities of isolated compounds from Ipomoea aquatica. | 2016 | |
| Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract. | 2016 | |
| Clinacanthus nutans: A review of the medicinal uses, pharmacology and phytochemistry. | 2016 | |
| An investigation into the anti-obesity effects of Morinda citrifolia L. leaf extract in high fat diet induced obese rats using a 1H NMR metabolomics approach. | 2016 | |
| Effect of Different Drying Treatments and Solvent Ratios on Phytochemical Constituents of Ipomoea aquatica and Correlation with α-Glucosidase Inhibitory Activity. | 2016 | |
| Metabolite profiling of Neptunia oleracea and correlation with antioxidant and α-glucosidase inhibitory activities using 1H NMR-based metabolomics. | 2016 | |
| Comparative evaluation of nutritional compositions, antioxidant capacities, and phenolic compounds of red and green sessile joyweed (Alternanthera sessilis). | 2016 | |
| Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract. | 2016 | |
| Chemical profiling of different types of soy sauce and the relationship with its sensory attributes. | 2016 | |
| Differentiation of fatty acid composition of butter adulterated with lard using gas chromatography mass spectrometry combined with principle compnent analysis. | 2016 | |
| Screening of various parts of Phaleria macrocarpa plant for α-glucosidase inhibitory activity. | 2015 | |
| Phytochemical diversity of Clinacanthus nutansextracts and their bioactivity correlations elucidated by NMR based metabolomics. | 2015 | |
| Phytochemical and biological features of Phyllanthus niruri and Phyllanthus urinaria harvested at different growth stages revealed by 1H NMR-based metabolomics. | 2015 | |
| Infrared–metabolomics approach in detecting changes in Andrographis paniculata metabolites due to different harvesting ages and times. | 2015 | |
| Multivariate analysis of PRISMA optimized TLC image for predicting antioxidant activity and identification of contributing compounds from Pereskia bleo. | 2015 | |
| Effect of storage time on metabolite profile and alpha-glucosidase inhibitory activity of Cosmos caudatus leaves – GCMS based metabolomics approach. | 2015 | |
| Metabolite profiling of Ipomoea aquatica at different growth stages in correlation to the antioxidant and α-glucosidase inhibitory activities elucidated by 1H NMR-based metabolomics. | 2015 | |
| Evaluation of antidiabetic properties of Momordica charantia in streptozotocin induced diabetic rats using metabolomics approach. | 2015 | |
| Relationship Between Metabolites Composition and Biological Activities of Phyllanthus niruri Extracts Prepared by Different Drying Methods and Solvents Extraction. | 2015 | |
| Detection of Butter Adulteration with Lard by Employing 1H-NMR Spectroscopy and Multivariate Data Analysis. | 2015 | |
| Detection of butter adulteration with lard using differential scanning calorimetry | 2015 | |
| FTIR-ATR Spectroscopy Based Metabolite Fingerprinting as A Direct Determination of Butter Adulterated With Lard. | 2015 | |
| Orthogonal Partial Least Squares Model for Rapid Prediction of Antioxidant Activity of Pereskia bleo by Fourier Transform Infrared Spectroscopy. | 2014 | |
| GC‐MS‐Based Metabolite Profiling of Cosmos caudatus Leaves Possessing Alpha‐Glucosidase Inhibitory Activity. | 2014 | |
| Effects of Different Drying Methods and Storage Time on Free Radical Scavenging Activity and Total Phenolic Content of Cosmos Caudatus. | 2014 | |
| Chemical characterization and antioxidant activity of three medicinal Apiaceae species. | 2014 | |
| Effect of Cosmos caudatus Kunth leaves on the lipid profile of a hyperlipidemia-induced animal model. | 2014 | |
| The Influence of Deep Frying Using Various Vegetable Oils on Acrylamide Formation in Sweet Potato (Ipomoea batatas L. Lam) Chips. | 2014 | |
| Comparison of Partial Least Squares and Artificial Neural Network for the prediction of antioxidant activity in extract of Pegaga (Centella) varieties from 1H Nuclear Magnetic Resonance spectroscopy. | 2013 | |
| Headspace solid-phase microextraction gas chromatography–mass spectrometry determination of volatile compounds in different varieties of African star apple fruit (Chrysophillum albidum). | 2013 | |
| Cosmos caudatus as a Potential Source of Bioactive Compounds: Optimisation of Oven Drying Conditions and Characterisation of its Functional Properties. | 2013 | |
| Simultaneous determination of aflatoxins, ochratoxin A, and zearalenone in cereals using a validated RP-HPLC method and phred derivatization system. | 2013 | |
| Quantification of Escherichia coli O157:H7 in organic vegetables and chickens. | 2013 | |
| Risk of Escherichia coli O157:H7 transmission linked to the consumption of raw milk. | 2013 | |
| Application of FTIR-ATR Spectroscopy Coupled with Multivariate Analysis for Rapid Estimation of Butter Adulteration. | 2013 | |
| Biochemical properties of red tilapia (Oreochromis niloticus) protein hydrolisates. | 2013 | |
| 1H-NMR-based metabolomics approach to understanding the drying effects on the phytochemicals in Cosmos caudatus. | 2012 | |
| High-performance liquid chromatographic determination of 5-hydroxymethyl furfural in roasted plantain cultivars. | 2012 | |
| Influence of Growth Stage and Season on the Antioxidant Constituents of Cosmos caudatus. | 2012 | |
| Plants’ Metabolites as potential Anti Obesity Agents. | 2012 | |
| Antioxidant activity of different extracts from leaves of Pereskia bleo (Cactaceae). | 2012 | |
| Volatile compounds of roasted and steamed Malaysian tropical almond nuts (T. catappa L). | 2012 | |
| Oxidative behaviour of four Malaysian edible plant extracts in model and food oil systems. | 2012 | |
| Discrimination of three Pegaga (Centella) varieties and determination of growth-lighting effects on metabolites content based on chemometry of 1H Nuclear Magnetic Resonance spectroscopy. | 2012 | |
| Role of health hazardeous ethephone on nutritive values of selected pineapple, banana and tomato. | 2012 | |
| A UPLC-MS/MS for simultaneous determination of aflatoxins, ochratoxin A, zearalenone, DON, fumonisins, T-2 toxin and HT-2 toxin, in cereals. | 2012 | |
| Metabolic characterization of green pods from Vanilla planifolia accessions grown in La Réunion. | 2011 | |
| Comprehensive Extraction Method Integrated with NMR Metabolomics: A New Bioactivity Screening Method for Plants, Adenosine A1 Receptor Binding Compounds in Orthosiphon stamineus Benth. | 2011 | |
| Antimicrobial activities of selected Malaysian plants against several food borne pathogen bacteria. | 2011 | |
| Discrimination of Young and Mature Leaves of Melicope ptelefolia using 1H NMR and Multivariate Data Analysis. | 2011 | |
| Metabolomics for bioactivity assessment of natural products. | 2011 | |
| Sample preparation optimization for the simultaneous determination of mycotoxins in cereals. | 2011 | |
| Simultaneous detection of 12 mycotoxins in cereals using RP-HPLC-PDA-FLD with PHRED and post-column derivatization system. | 2011 | |
| Extraction of fish oil from the skin of Indian mackerel using supercritical fluids. | 2010 | |
| Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L. | 2010 | |
| Fatty Acid Compositions of Fish Oil Extracted from Different Parts of Indian Mackerel (Rastrellinger kanagurta) using Various Techniques of Supercritical CO2 Extraction. | 2010 | |
| Application of Two Dimensional Thin Layer Chromatography Pattern Comparison for Fingerprinting the Active Compounds in the Leaves of Vitex trifolia Linn Possessing Anti-Tracheospasmolytic Activity. | 2010 | |
| The Application of β-Cyclodextrin to Separate cis- from trans- Iso-alpha-Acids in an Isomerized Hop Extract. | 2010 | |
| Isolation of individual hop iso-alfa-acids stereoisomers by beta-cyclodextrin. | 2010 | |
| Storage stability of fish oil from Langkawi island, Malaysia. | 2009 | |
| Metabolic changes in different developmental stages of Vanilla planifolia pods. | 2009 | |
| Identification of Possible Compounds Possessing Adenosine A1 Receptor Binding Activity in the leaves of Orthosiphon stamineus Using TLC and Multivariate Data Analysis. | 2009 | |
| Adenosine A1 Receptor Binding Activity of Methoxy Flavonoids from Orthosiphon stamineus. | 2009 | |
| NMR assignment of iso-alpha-acids from isomerized extract of Humulus lupulus L., cones. | 2007 | |
| High performance liquid chromatography method of iso-alpha-acids. | 2006 | |
| Anti-inflammatory activities of Cinnamomum burmanni Bl. | 2005 | |
| Studies of iso-alpha-acids. | 2006 | |
| Method of improving the stability of hop extracts and hop flavored beverages. | 2006 | |
| Allergenicity study of white shrimp proteins (Paneus marguensis) for allergen isolate production. | 1998 | |
| Characterization of tuna gastric protease as a rennet substitute. | 1996 |
Keanggotaan dan Penghargaan
| Nama | Tahun | Organisasi Pemberi |
|---|---|---|
| The winner of the Dutch New Venture Competition Round 2 | 2006 | Duth Government |
| Excellent Achievement, | 2009-2011 | Universiti Putra Malaysia |
| Gold Medal for the invention of “FTIR-ATR Spectroscopy based metabolite fingerprinting as a direct determination of butter adulerated with lard” | 2012 | Universiti Putra Malaysia |
| Gold Medal for the invention of “Analysis of Butter Adulterated with Lard by FTIR and 1H-NMR for Halal Verification” | 2012 | Universiti Teknologi Mara Melaka |
| Department Best Non-Indexed Journal Articles | 2015 | International Islamic University Malaysia |
| Outstanding Contributor for Journal Articles Indexed in SCOPUS and WOS 2016 | 2016 | International Islamic University Malaysia |
| The Most Productive Researcher Award | 2017 | International Islamic University Malaysia |
| Highest Number of Publication in Citation-Indexed Journals Award (Health and Medical). | 2017 | International Islamic University Malaysia |
| Best Journal Article Awards (Medical and Health Science) | 2018 | International Islamic University Malaysia |
| Highest Number of Publications Award: Indexed Journal Articles (Medical and Health Sciences) | 2018 | International Islamic University Malaysia |
| Outstanding contribution in Reviewing | 2018 | Phytomedicine-Elsevier |
Daftar Hibah yang Diperoleh
| Judul, role | Tahun | Jumlah Dana | Pemberi Hibah |
|---|---|---|---|
| Understanding Anti-Angiogenesis Mechanism of Porcupine Bezoar Bioactive Compounds on Colon and Pancreas Cancer Cells Using Xenograft Zebrafish Model, anngota | 2016-sekarang | RM 100,000 | Fundamental Research Grant Scheme (FRGS) from Malaysian Ministry of Higher Education |
| Understanding of anti-cancer properties of Neolamarckia cadamba leaves on breast cancer: Prospective therapeutic Neolamarckia cadamba extracts, Principal Investigator | 2016-sekarang | RM 52,200 | Fundamental Research Grant Scheme (FRGS) from Malaysian Ministry of Higher Education |
| Multivariate calibration of anti-oxidant activity of Momordica charnatia fruit and its Fourier Transform Infra Red spectroscopy-based fingerprinting, Principal Investigator | 2016-2017 | RM 20,000 | Research Initiative Grant Scheme from Malaysian Ministry of Higher Education |
| Evaluation of External Application of Halal Topical Cream of Neolamarckia Cadamba Leaves on Breast Cancer Cells in Rats Leading Towards Clinical Trial on Human Breast Cancer, member | 2015-2016 | RM 25,000 | Research Initiative Grant Scheme from Malaysian Ministry of Higher Education |
| Effect of Standardized Extract of Clinacanthus Nutans in Hiperuricemia Induced Mice, member | 2014-2017 | RM 400,000 | NKEA Research Grant Scheme (NRGS), Malaysia Ministry of Agriculture |
| Production of Chemical Markers From Labisia Pumila (Labisiaquinones B and Two Alkylresorcinols and Clinacanthus Nutans) Clinacosides A,B,C and Cycloclinacoside A2, Principal Investigator | 2013-2015 | RM 50,000 | NKEA Research Grant Scheme (NRGS), Malaysia Ministry of Agriculture |
| Chemical Profiling of Mommordica Charantia Possessing Alpha-Glucosidase Inhibitory Activity using GC-MS based Metabolomics, member | 2014-2016 | RM 50,000 | Research Acculturation Collaborative Effort (RACE) grant from Malaysian Ministry of Higher Education |
| Upscaling the Production of Novel Fucoxanthin from Malaysian Brown Algae for Food and Pharmaceutical Applications, member | 2015-2016 | RM 130,000 | Prototype Research Grant Scehme (PRGS) from Malaysian Ministry of Higher Education |
| Fingerprinting of Sygygium Companulatum (Kelat Paya) Leaf Extracts Utilizing Gas Chromatography-Mass Spectrometery (GC-MS) and Metabolomics for their Quality and Efficacy Profile, member | 2014-2016 | RM 20,000 | Endowment type B, International Islamic University Malaysia |
| Comprehensive evaluation of anti-diabetic activity of Momordica charantia fruits on streptozotocin induced diabetic rats using NMR metabolomics approach, Principal Investigator | 2013-2015 | RM 20,000 | Endowment type B, International Islamic University Malaysia |
| Development of Validated Regression Model to Correlate Chemical Profile of the Leaves of Orthosiphon stamineus extract to Anti-Diabetic Activity using NMR and FTIR-based Metabolomics Approach, member | 2011-2013 | RM 400,000 | NKEA Research Grant Scheme (NRGS), Malaysia Ministry of Agriculture |
| NMR based-metabolomics assessment of anti-diabetic effect of Cymbopogon citratus leaves on streptozotocin-induced diabetic rat, principal investigator | 2012-2013 | RM 100,000 | Research University Grant Scheme (RUGS) Initiative 2 from UPM |
| Metabolomics study for the development of functional foods with anti-diabetic property, principal investigator | 2011-2012 | RM 370,000 | Agro-Biothechnology R&D Initiatives, MOSTI |
| NMR based metabolomic biofluids of standardized Centella asiatica extract in the detection of physiological changes in rats induced diabetes, member | 2010-2012 | RM 60,000 | Fundamental Research Grant Scheme (FRGS) from Malaysian Ministry of Higher Education |
| Study on antibacterial activity of Malaysian herbs and spices against food borne pathogen and food spoilage, principal investigator | 2009-2011 | RM 30,000 | Research University Grant Scheme (RUGS) Initiative 4 from UPM |
| Feasibility study of the production of pure individual iso-alpha-acids, principal investigator | 2006-2007 | Euro 25,000 | Dutch Valorization Grant |
Anggota Asosiasi Profesional
| Judul | Tahun |
|---|---|
| American Chemical Society | 2009-sekarang |
| Malaysian Natural Product Society | 2015-sekarang |
| Malaysian Institute of Technology | 2013-sekarang |